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Double Blind Randomized Control Test for the Usefulness of Mastic Compound Dentifrice Against Periodontitis

Double Blind Randomized Control Test for the Usefulness of Mastic Compound Dentifrice Against Periodontitis under Using Sonic Toothbrush


WATANABE Hisashi ; HAGIWARA Satsuki ; FUKUDA Motohisa ; YUICHI Izumi ; TAMURA Noriko ; SUZUKI Masamitsu ; KAWASAKI Daisuke ; FUKAHORI Masahiro ;



Mastic is a resinous exudate obtained from stem and main leaves of Pistacia lentiscus. The aim of the present study was to assess clinical and microbiological effect of mastic-essential-oil compound dentifrice (MD) on chronic periodontitis under using sonic toothbrush (SB), in a randomized control trial. Twenty two volunteers with chronic periodontitis were assigned in random to two groups ; the experimental group (SB+MD): 11 patients (6 males, 5 females, mean age 63.2 years) and the placebo group (SB+non-MD): 11 patients (4 males, 7 females, mean age 55.5 years). 3 sites per each were subjected. At baseline and at 2, 4 and 12 weeks, clinical measurements were performed using clinical parameters. In addition, subgingival plaque was collected at baseline and at 4 and 12 weeks. A quantitative analysis of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Tannerella forsythia, Prevotella intermedia were carried out using real-time polymerase chain reaction (PCR) procedures. There was no significant difference between two groups as to the clinical conditions at base line. Significant decreased inflammation was noted after using sonic toothbrush and dentifrice for 2, 4 and 12 weeks in both mastic group and placebo. As to swelling, bleeding, redness of gingiva and plaque accumulation, mastic group showed a significant improvement compared to the control (p<0.05). A significant suppression of P. gingivalis and red complex in the ratio against total bacteria cell counts after 4 week treatment, and P. gingivalis and P. inter-media after 12 week treatment were observed in only mastic group (P<0.05). In addition, the test group was significantly superior to the placebo as to the suppression of P. gingivalis at 12 weeks after treatment (P<0.05). This study suggests that sonic toothbrush and dentifrice may be useful for chronic periodontitis, and the useful effect for chronic periodontitis may cause the anti periodontal-pathogen by mastic-essential-oil.

Journal Title

Yakuri to chiryo    ISSN  0386-3603   CODEN YACHDS 


2010, vol. 38, no10, pp. 915-925 [11 page(s) (article)]




Life Science, Tokyo, JAPON  (1973) (Revue)

Author Keywords

Mastic, Sonic toothbrush, Periodontitis

Localisation / Location

INIST-CNRS, Cote INIST : 20717, 35400019458596.0050